Ammonium Chloride → 4-Azido-5-bromo-1H-pyrrolo[2,3-b]pyridine
反応式
[Br:1][C:2]1[C:3](Cl)=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[N-:12]=[N+:13]=[N-:14].[Na+].[Cl-].[NH4+]>CN(C)C=O.O>[N:12]([C:3]1[C:2]([Br:1])=[CH:7][N:6]=[C:5]2[NH:8][CH:9]=[CH:10][C:4]=12)=[N+:13]=[N-:14]参加物
6
反応条件
- 温度
- 110 °C
実験手順
5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine (1.5 g, 6.5 mmol), sodium azide (2.11 g, 32 mmol), and ammonium chloride (1.73 g, 32 mmol) were suspended in anhydrous dimethylformamide (10 mL). The reaction was heated to 110° C. for 19 h. The reaction mixture was diluted with water and the solids were collected. The solids were dissolved in a mixture of acetone and ethylacetate, the solution was filtered and concentrated to afford 4-Azido-5-bromo-1H-pyrrolo[2,3-b]pyridine (670 mg, 2.8 mmol, 43%). MS: m/z 238.0/240.0 (M+H+).
後処理
- customthe solids were collected
- dissolutionThe solids were dissolved in a mixture of acetone and ethylacetate
- filtrationthe solution was filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-14b04ee981084b10aae1b31999ea4caf
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158647B2
反応ノート
読み込み中…