Trifluoroacetic acid → HCID 57537545、化合物
反応式
[Br:1][C:2]1[C:3]([Cl:31])=[C:4]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH2:17][O:18]C(C)(C)C)=[CH:9][N:8](COCC[Si](C)(C)C)[C:5]2=[N:6][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[C:3]([Cl:31])=[C:4]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH2:17][OH:18])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- 23 °C
実験手順
5-Bromo-3-(2-tert-butoxymethyl-phenyl)-4-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine (66 mg, 0.12 mmol) was dissolved in dichloromethane (1 mL) and trifluoroacetic acid (1 mL) and stirred at 23° C. for 15 h. The solvent was evaporated and the resulting oil was dissolved in methanol (1 mL) and ethylenediamine (0.2 mL) and stirred at 23° C. for 1 h. The mixture was concentrated to afford [2-(5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-phenyl]-methanol which was used in the next step without further purification.