Diisopropylethylamine → HCID 67279039、化合物

HRID 1694336ノート

反応式

HRID 1694336 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[S:7])=[CH:4][CH:3]=1.[F:12][CH:13]([F:23])[O:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH:17]=O.CCN(C(C)C)C(C)C>C(Cl)Cl>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]2[S:7][CH:17]([C:16]3[CH:19]=[CH:20][CH:21]=[CH:22][C:15]=3[O:14][CH:13]([F:12])[F:23])[NH:9][N:8]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 27369842-(Difluoromethoxy)benzaldehydeHCID 124770754-Chloro-thiobenzoic acid hydrazide

生成物 1

HCID 67279039HCID 67279039、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a heterogeneous mixture of 4-chloro-thiobenzoic acid hydrazide (0.107 mmol) in CH2Cl2 (1 mL) is added 2-difluoromethoxy-benzaldehyde (0.128 mmol) and DIEA (0.128 mmol). After 10 minutes the mixture become homogenous and the reaction is complete by TLC and LCMS to give 5-(4-chloro-phenyl)-2-(2-difluoromethoxy-phenyl)-2,3-dihydro-[1,3,4]thiadiazole which is used in the next step without evaporation of the solvent.

出典と根拠

ORDレコード
ord-41cafef04c114c48a532a482a33cc848
出典データセット
uspto-grants-2012_04
特許番号
US08158662B2

反応ノート

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