Trifluoroacetic acid → {[5-Chloro-4'-(ethylthio)biphenyl-2-yl]oxy}acetic acid
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH2:15][CH3:16])=[CH:10][CH:9]=2)[CH:7]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([S:14][CH2:15][CH3:16])=[CH:12][CH:13]=2)[CH:7]=1参加物
4
実験手順
The title compound was prepared by stirring a mixture of the product from step (ii) (0.3 g) and trifluoroacetic acid (4 ml) in DCM (10 ml) at RT for 5 h. The solvent was evaporated under reduced pressure, the residue triturated with diethylether then purified by reverse phase HPLC. Yield 0.106 g
後処理
- customThe solvent was evaporated under reduced pressure
- customthe residue triturated with diethylether
- customthen purified by reverse phase HPLC
出典と根拠
- ORDレコード
- ord-38685364f43447d9b553ecdadb2461d0
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158820B2
反応ノート
読み込み中…