Sodium Carbonate → HCID 67280484、化合物
反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1B(O)O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:20]1[CH:21]=[N:22][CH:23]=[N:24][CH:25]=1.C(=O)([O-])[O-].[Na+].[Na+]>O1CCOCC1>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:20]1[CH:21]=[N:22][CH:23]=[N:24][CH:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of the product from step (ii) (0.2 g), 5-bromopyrimidine (0.16 g), sodium carbonate (0.21 g) and tetrakistriphenylphosphine palladium (0) (0.05 g) in dioxane (6 ml) was heated under reflux for 48 h. The mixture was partitioned between EtOAc and water, the organics separated, dried, and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 20% EtOAc/isohexane. Yield 0.283 g.