Isoamyl Nitrite → 2-Chloro-4-(ethylthio)-1-iodo-benzene

HRID 1694707

反応式

HRID 1694707 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[I:9])N.C(ON=O)CC(C)C.[CH2:18]([S:20]SCC)[CH3:19]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([S:20][CH2:18][CH3:19])[CH:6]=[CH:7][C:8]=1[I:9]

参加物

5

反応物 3

HCID 8053Isoamyl NitriteHCID 8077Diethyl disulfideHCID 2829263-Chloro-4-iodoaniline

生成物 1

HCID 672801852-Chloro-4-(ethylthio)-1-iodo-benzene

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 3-chloro-4-iodo-aniline (5.6 g), isoamylnitrite (8.8 ml) and ethyldisulphide (13.4 ml) in acetonitrile (100 ml) was heated at 60° C. for 24 h. The solvent was removed under reduced pressure and the residue purified by chromatography on silica eluting with 1% ethylacetate/isohexane. Yield 4.02 g

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified by chromatography on silica eluting with 1% ethylacetate/isohexane

出典と根拠

ORDレコード
ord-7c48071fe59d41d998676c0323da739d
出典データセット
uspto-grants-2012_04
特許番号
US08158820B2

関連ノート

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