Bromine → HCID 67280002、化合物

HRID 1694712ノート

反応式

HRID 1694712 の反応式
[Br:1]Br.[CH2:3]([S:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[CH3:4]>C(Cl)(Cl)Cl.C(Cl)Cl>[Br:1][C:9]1[CH:10]=[CH:11][C:6]([S:5][CH2:3][CH3:4])=[CH:7][C:8]=1[F:12]

参加物

5

反応物 2

HCID 24408BromineHCID 179099581-(Ethylsulfanyl)-3-fluorobenzene

生成物 1

HCID 67280002HCID 67280002、化合物

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6344Dichloromethane溶媒

実験手順

Bromine (0.3 ml) was added to a solution of 1-ethylsulfanyl-3-fluoro-benzene (1 g) in chloroform (20 ml) at 0° C. then warmed to RT. After 2 h the mixture was diluted with DCM, washed with aq. sodium thiosulphate solution, dried, and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 10% diethylether/iso-hexane. Yield 1.2 g

後処理

  1. washwashed with aq. sodium thiosulphate solution
  2. customdried
  3. customevaporated under reduced pressure
  4. customThe residue was purified by chromatography on silica eluting with 10% diethylether/iso-hexane

出典と根拠

ORDレコード
ord-60c9d2cf456a403eaad9ee98f4df1d11
出典データセット
uspto-grants-2012_04
特許番号
US08158820B2

反応ノート

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