関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Pyrimidine, 2,4-dichloro-5-methyl- | HCID 74508 | — |
| 反応物 | HCID 178486264 | HCID 178486264 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-(4-Chloro-5-methylpyrimidin-2-YL)-N-methylmethanesulfonamide | HCID 72211794 | — |
反応手順
A mixture of N-methylsulphonamide (3.35 g), 2,4-dichloro-5-methylpyrimidine (5 g) and potassium carbonate (4.3 g) in DMF (50 ml) was heated at 80° C. for 4 h. The reaction was quenched with water (200 ml) and extracted with ethylacetate. The organics were dried, evaporated under reduced pressure and the residue triturated with ether. The solid was filtered off (4-isomer) and the filtrate evaporated under reduced pressure and subjected to RPHPLC to obtain the 2-isomer, yield 0.37 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08158820B2 |
|---|
| 出典データセット | uspto-grants-2012_04 |
|---|
| ORD ID | ord-86007e06b1a2473aa58df9d9b94b2f1b |
|---|
| 出典メモ | uspto-grants-2012_04 |
|---|
