反应详情

温度

80 °C

A mixture of N-methylsulphonamide (3.35 g), 2,4-dichloro-5-methylpyrimidine (5 g) and potassium carbonate (4.3 g) in DMF (50 ml) was heated at 80° C. for 4 h. The reaction was quenched with water (200 ml) and extracted with ethylacetate. The organics were dried, evaporated under reduced pressure and the residue triturated with ether. The solid was filtered off (4-isomer) and the filtrate evaporated under reduced pressure and subjected to RPHPLC to obtain the 2-isomer, yield 0.37 g.

1. customThe reaction was quenched with water (200 ml)
2. extractionextracted with ethylacetate
3. customThe organics were dried
4. customevaporated under reduced pressure
5. customthe residue triturated with ether
6. filtrationThe solid was filtered off (4-isomer)
7. customthe filtrate evaporated under reduced pressure
8. customto obtain the 2-isomer, yield 0.37 g