反応式
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[CH3:12])=[O:5])C.[OH-].[Na+].Cl>CO.O>[CH3:12][N:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[C:4]([OH:5])=[O:3]参加物
6
実験手順
N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.
後処理
- customevaporated to dryness
- customevaporated four times with toluene
出典と根拠
- ORDレコード
- ord-9f4e30bfc478409492ed3c628979e11d
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163698B2
関連ノート
読み込み中…