1,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate → HCID 67277260、化合物

HRID 1695120ノート

反応式

HRID 1695120 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9]>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9]

参加物

3

反応物 1

HCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

生成物 1

HCID 67277260HCID 67277260、化合物

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe mixture was azeotroped with toluene
  3. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

出典と根拠

ORDレコード
ord-27a99210d77d48b3832c6c33a4259644
出典データセット
uspto-grants-2012_04
特許番号
US08163727B2

反応ノート

読み込み中…