Methanol → [[3'-Fluoro-4'-[(1-methylethyl)sulfonyl]-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]acetic acid

HRID 1695126ノート

反応式

HRID 1695126 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:15]=2[O:24][CH2:25][C:26]([O:28]C)=[O:27])[CH:5]=[CH:6][C:7]=1[S:8]([CH:11]([CH3:13])[CH3:12])(=[O:10])=[O:9].CO>[OH-].[Na+]>[F:1][C:2]1[CH:3]=[C:4]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:15]=2[O:24][CH2:25][C:26]([OH:28])=[O:27])[CH:5]=[CH:6][C:7]=1[S:8]([CH:11]([CH3:13])[CH3:12])(=[O:10])=[O:9]

参加物

4

反応物 2

HCID 887MethanolHCID 91026486Methyl [[3'-fluoro-4'-[(1-methylethyl)sulfonyl]-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]acetate

生成物 1

HCID 11704460[[3'-Fluoro-4'-[(1-methylethyl)sulfonyl]-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]acetic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of the product from step e) (140 mg) in NaOH (0.35 ml, 1 M), THY (2 ml) and MeOH (1 ml) was stirred for 2 h. The solvent was removed in vacuo and the residue was washed with ether, acidified (2M HCl) and extracted with DCM (thrice). The organic extracts were dried (MgSO4), evaporated and crystallised from isohexane—DCM to give the title compound (105 mg). M.p. 170-1° C.

後処理

  1. customThe solvent was removed in vacuo
  2. washthe residue was washed with ether
  3. extractionextracted with DCM (thrice)
  4. dry with materialThe organic extracts were dried (MgSO4)
  5. customevaporated
  6. customcrystallised from isohexane—DCM

出典と根拠

ORDレコード
ord-8eca094a94914f419a55e077fa534f7f
出典データセット
uspto-grants-2012_04
特許番号
US08163727B2

反応ノート

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