Hydrochloric Acid → Methyl (4-chloro-2-iodophenoxy)acetate
反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]([I:9])=[C:6]([OH:8])[CH:7]=1.Br[CH2:11][C:12]([O:14][CH3:15])=[O:13].C(=O)([O-])[O-].[K+].[K+].[ClH:22]>C(#N)C>[Cl:22][C:3]1[CH:2]=[CH:7][C:6]([O:8][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[C:5]([I:9])[CH:4]=1参加物
6
実験手順
A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol—ether as eluent) to give the sub-title compound (5.75 g).
後処理
- temperaturewas heated
- temperatureunder reflux for 2 h
- extractionthe mixture was extracted with ether (three times)
- dry with materialThe organic extracts were dried (MgSO4)
- customevaporated
- custompurified by chromatography (silica, petrol—ether as eluent)
出典と根拠
- ORDレコード
- ord-30d0839d0b5342eea5331aedeb3431ea
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163727B2
反応ノート
読み込み中…