Methanol → Methyl 4-bromo-2-methylbutanoate
反応式
[Br:1][CH2:2][CH2:3][CH:4]([CH3:8])[C:5](Br)=[O:6].[CH3:9][OH:10]>C(Cl)(Cl)Cl>[CH3:9][O:10][C:5](=[O:6])[CH:4]([CH3:8])[CH2:3][CH2:2][Br:1]参加物
4
実験手順
A solution of 4-bromo-2-methyl-butyryl bromide (6.2 g, 43.0 mmol, 1.0 eq) in CHCl3 (10 mL) was cooled at 0° C. MeOH (10 mL) was slowly added and the resulting mixture stirred at room temperature for 16 hours. The solvent was evaporated and the residue dissolved in CHCl3 and washed with water and brine. The organic layer was collected and dried with Na2SO4. Evaporation of the solvent gave 4-bromo-2-methyl-butyric acid methyl ester as thick oil (4.3 g, yield 51%).
後処理
- customThe solvent was evaporated
- dissolutionthe residue dissolved in CHCl3
- washwashed with water and brine
- customThe organic layer was collected
- dry with materialdried with Na2SO4
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-8802e8e0de3240fdb0704d4d3ad22367
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163729B2
反応ノート
読み込み中…