Isopropylamine → 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid isopropylamide

反応式

CO[C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4].[CH:22]([NH2:25])([CH3:24])[CH3:23]>>[CH:22]([NH:25][C:3]([C:5]1[NH:6][N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=[O:4])([CH3:24])[CH3:23]

参加物

反応物 2

HCID 6363Isopropylamine

HCID 66643879HCID 66643879、化合物

生成物 1

HCID 595684065-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid isopropylamide収率 89%

実験手順

As described for example 26d, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.34 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (97 mg, 89%) which was obtained as a colorless oil. MS: m/e=321.3 [M+H]+.

出典と根拠

ORDレコード: ord-9327d3a81fd04c209298b5dcd1a72add
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08163728B2

反応ノート

読み込み中…