反応式
CO[C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[N:7]([CH3:24])[N:6]=1)=[O:4].[NH2:25][CH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[O:29]1[CH2:30][CH2:31][CH:26]([NH:25][C:3]([C:5]2[CH:9]=[C:8]([O:10][CH2:11][C:12]3[C:13]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=4)=[N:14][O:15][C:16]=3[CH3:17])[N:7]([CH3:24])[N:6]=2)=[O:4])[CH2:27][CH2:28]1参加物
3
実験手順
As described for example 115, 1-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl ester (70 mg, 0.21 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (76 mg, 90%) which was obtained as a colorless oil. MS: m/e=398.2 [M+H]+.
出典と根拠
- ORDレコード
- ord-696ed96c64e044eb89db345eedc7a775
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163728B2
関連ノート
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