Potassium Carbonate → 2-(1-(2-Nitrophenyl)ethylamino)acetonitrile

HRID 1695515ノート

反応式

HRID 1695515 の反応式
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])([O-:3])=[O:2].[C:12]([O-])([O-])=O.[K+].[K+].C[CH:19](Br)[C:20]#[N:21]>C(#N)C>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]([NH:7][CH2:19][C:20]#[N:21])[CH3:12])([O-:3])=[O:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 1405382-BromopropionitrileHCID 423893(2-Nitrophenyl)methanamine

生成物 1

HCID 866252282-(1-(2-Nitrophenyl)ethylamino)acetonitrile

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
65 °C

実験手順

2-Nitrobenzylamine (513 mg, 3.37 mmol) was added to an acetonitrile (40 mL) containing K2CO3 (932 mg, 6.74 mmol) and 2-bromopropanitrile (677 mg, 5.06 mmol) under a nitrogen atmosphere. The reaction mixture was heated to 65° C. for 14 hours. The product (18) was used without purification or concentration in the next step.

後処理

  1. customThe product (18) was used without purification or concentration in the next step

出典と根拠

ORDレコード
ord-8046259b90de42408c5cb640d8abaafc
出典データセット
uspto-grants-2012_04
特許番号
US08163738B2

反応ノート

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