Sodium borohydride → 4-FLUORO-N-[5-(1-HYDROXY-ETHYL)-INDAN-2-yl]-BENZAMIDE

HRID 1695572ノート

反応式

HRID 1695572 の反応式
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([NH:13][C:14](=[O:22])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[CH2:7]2)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:14]([NH:13][CH:8]2[CH2:7][C:6]3[C:10](=[CH:11][CH:12]=[C:4]([CH:1]([OH:3])[CH3:2])[CH:5]=3)[CH2:9]2)=[O:22])=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 21920974N-(5-Acetyl-indan-2-YL)-4-fluoro-benzamide

生成物 1

HCID 219211674-FLUORO-N-[5-(1-HYDROXY-ETHYL)-INDAN-2-yl]-BENZAMIDE

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

400 mg (1.35 mmol) N-(5-acetyl-indan-2-yl)-4-fluoro-benzamide were dissolved in 10 ml of methanol, then 100 mg (2.7 mmol) sodium borohydride were added. The mixture was worked up by dropping onto ice/HCl, the resulting solid was filtered off.

後処理

  1. filtrationthe resulting solid was filtered off

出典と根拠

ORDレコード
ord-51d7265b3dcf4f578852d6ad6333a988
出典データセット
uspto-grants-2012_04
特許番号
US08163751B2

反応ノート

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