Benzenesulfonyl chloride → N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide

HRID 1695754ノート

反応式

HRID 1695754 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1.[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([NH:11][S:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:20])=[O:19])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 7369Benzenesulfonyl chlorideHCID 532116995-Bromo-2-ethoxypyridin-3-amine

生成物 1

HCID 59860135N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 5-bromo-2-(ethyloxy)-3-pyridinamine (1.45 g) in anhydrous pyridine (15 ml) was treated with benzenesulfonyl chloride (1.03 ml) then stirred at RT for 20 hr. The reaction was evaporated to dryness and the residue was purified by column chromatography on silica, eluting with 30% hexanes in DCM, to give the title compound (1.86 g).

後処理

  1. customThe reaction was evaporated to dryness
  2. customthe residue was purified by column chromatography on silica
  3. washeluting with 30% hexanes in DCM

出典と根拠

ORDレコード
ord-087614375e224ad2a79c1264e1426db0
出典データセット
uspto-grants-2012_04
特許番号
US08163743B2

反応ノート

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