CCN(C(C)C)C(C)C.[CH:10]1([C:13](Cl)=[O:14])[CH2:12][CH2:11]1.O1CCCCC1[N:22]1[CH:30]=[C:29]2[C:24]([CH:25]=[C:26]([C:32]3[CH:37]=[CH:36][C:35]([O:38]C4CCCCO4)=[CH:34][CH:33]=3)[CH:27]=[C:28]2[NH2:31])=[N:23]1>C(Cl)Cl>[OH:38][C:35]1[CH:34]=[CH:33][C:32]([C:26]2[CH:25]=[C:24]3[C:29]([CH:30]=[N:22][NH:23]3)=[C:28]([NH:31][C:13]([CH:10]3[CH2:12][CH2:11]3)=[O:14])[CH:27]=2)=[CH:37][CH:36]=1DIPEA (82 mg, 0.635 mmol) and cyclopropanecarbonyl chloride (15 mg, 0.14 mmol) were added to 2-(tetrahydro-2H-pyran-2-yl)-6-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazol-4-amine (50 mg, 0.127 mmol) in DCM (1 ml) and the reaction was stirred for 1 h. The solvent was removed under a stream of nitrogen. The residue was dissolved in MeOH (2 ml), 4 M HCl in 1,4-dioxane (2 ml) was added and the reaction was stirred for 1 h. The solvent was removed in vacuo. The residue was purified by MDAP (Method B), dried under a stream of nitrogen then freeze dried to give the title compound, 17 mg.
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