(s)-2-Mercaptosuccinic acid → 2-(2-(2-(2-(Dimethylamino)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid

HRID 1695937

反応式

HRID 1695937 の反応式
[CH3:1][C:2]([CH3:21])([CH3:20])[CH2:3][CH2:4]/[N:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[C:8]=1[NH:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18].[SH:22][C@@H:23]([CH2:27][C:28]([OH:30])=[O:29])[C:24](O)=[O:25]>C1(C)C=CC=CC=1>[CH3:18][N:17]([CH3:19])[CH2:16][CH2:15][NH:14][C:8]1[C:9]([F:13])=[CH:10][CH:11]=[CH:12][C:7]=1[CH:6]1[N:5]([CH2:4][CH2:3][C:2]([CH3:21])([CH3:20])[CH3:1])[C:24](=[O:25])[CH:23]([CH2:27][C:28]([OH:30])=[O:29])[S:22]1

参加物

4

反応物 2

HCID 3246154(s)-2-Mercaptosuccinic acidHCID 178483753HCID 178483753、化合物

生成物 1

HCID 766019922-(2-(2-(2-(Dimethylamino)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2-((E)-(3,3-dimethylbutylimino)methyl)-N-(2-(dimethylamino)ethyl)-6-fluorobenzenamine (175 mg, 0.5964 mmol) and (S)-2-mercaptosuccinic acid (102 mg, 0.6793 mmol) were stirred in toluene (7 mL) at 80° C. for 24 hours. Crude 2-(2-(2-(2-(dimethylamino)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid was obtained as a brown oil and carried on to the next reaction.

出典と根拠

ORDレコード
ord-87266a0698224c2dbd67da46cfd3d94f
出典データセット
uspto-grants-2012_04
特許番号
US08163737B2

関連ノート

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