Sodium borohydride → Sulfonylpyran-4-ol

HRID 1696

反応式

HRID 1696 の反応式
[S:1](=[C:4]1[CH2:9][C:8](=[O:10])[CH:7]=[CH:6][O:5]1)(=[O:3])=[O:2].[BH4-].[Na+]>CO>[S:1](=[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][O:5]1)(=[O:3])=[O:2]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 19691003Sulfonylpyran-4-one

生成物 1

HCID 19690976Sulfonylpyran-4-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A stirred solution of sulfonylpyran-4-one (1.2 g, 8.1 mmol) in MeOH (20 mL) was cooled to 0° C. under Argon and treated with NaBH4 (331 mg, 9.0 mmol). The reaction was stirred over 16 h and allowed to warm to ambient temperature. The solvent was removed under reduced pressure and the crude oil was chromatographed on a silica gel column packed in 50:50 EtOAc:hexanes and eluted with same. The appropriate fractions were combined and the solvent was removed under reduced pressure to give the sulfonylpyran-4-ol.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe crude oil was chromatographed on a silica gel column
  3. washhexanes and eluted with same
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a131d665a87f4613af62e1177a8607d3
出典データセット
uspto-grants-1998_03
特許番号
US05726172

関連ノート

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