Trifluoroacetic acid → (2,7-Dioxo-5,6,7,8-tetrahydro-4H-imidazo[1,5,4-fg][1,6]-benzodiazocin-1(2H)-yl)acetic Acid
反応式
[O:1]=[C:2]1[CH:16]([CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[C:15]2[N:14]=[CH:13][N:6]3[CH2:7][C:8](=[O:12])[CH2:9][CH2:10][NH:11][C:4]([C:5]=23)=[CH:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:1]=[C:2]1[CH:16]([CH2:17][C:18]([OH:20])=[O:19])[C:15]2[N:14]=[CH:13][N:6]3[CH2:7][C:8](=[O:12])[CH2:9][CH2:10][NH:11][C:4]([C:5]=23)=[CH:3]1参加物
4
実験手順
To a solution of tert-butyl (2,7-dioxo-5,6,7,8-tetrahydro-4H-imidazo[1,5,4-fg][1,6]benzodiazocin-1(2H)-yl)acetate from Step D (15 mg, 0.045 mmol) in CH2Cl2 (3 mL) was added TFA (1 mL). After 2 h, the mixture was concentrated under reduced pressure to give the title compound. MS: m/z=276 (M+1).
後処理
- concentrationthe mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e6d95a0219a9487fa5d34ee7d107ac17
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163752B2
反応ノート
読み込み中…