HCID 18943563、化合物 → HCID 18943538、化合物
反応式
[F:1][C:2]([F:20])([F:19])[C:3]([N:5]1[CH2:11][CH2:10][C:9]2[CH:12]=[C:13]([N+:16]([O-])=O)[CH:14]=[CH:15][C:8]=2[CH2:7][CH2:6]1)=[O:4]>CO.[Pd]>[NH2:16][C:13]1[CH:14]=[CH:15][C:8]2[CH2:7][CH2:6][N:5]([C:3](=[O:4])[C:2]([F:20])([F:1])[F:19])[CH2:11][CH2:10][C:9]=2[CH:12]=1参加物
4
実験手順
To a suspension of 2,2,2-trifluoro-1-(7-nitro-1,2,4,5-tetrahydrobenzo[d]azepin-3-yl)ethanone (1.1 mmol) in MeOH (5 mL) was added 10% Pd/C and the mixture was stirred at RT under H2 (1 atm) for 24 h. After filtration, the filtrate was concentrated to afford 1-(7-amino-1,2,4,5-tetrahydrobenzo[d]azepin-3-yl)-2,2,2-trifluoroethanone (0.27 g, 95% yield). LC-MS (EI) m/z: 259.0 (M+H+).
後処理
- filtrationAfter filtration
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-021da8be70304e50a39ba9d34ead1114
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163756B2
反応ノート
読み込み中…