Hydrochloric Acid → 2-Mercapto-4-methoxyphenol

HRID 1696714ノート

反応式

HRID 1696714 の反応式
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]2[O:12]C(=O)[S:10][C:9]=2[CH:14]=1.Cl>C(O)C>[SH:10][C:9]1[CH:14]=[C:5]([O:4][CH3:3])[CH:6]=[CH:7][C:8]=1[OH:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1370241,3-Benzoxathiol-2-one, 5-methoxy-

生成物 1

HCID 127877572-Mercapto-4-methoxyphenol収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
65 °C

実験手順

Aqueous 2 N sodium hydroxide solution (44.7 mL) was added to an ethanol solution of the compound (7.76 g, 42.6 mmol) synthesized in the above (1), and stirred in a nitrogen atmosphere at 65° C. for 1.5 hours. The reaction liquid was neutralized with aqueous 5 N hydrochloric acid solution, and extracted twice with chloroform. The organic layer was dried with magnesium sulfate, and concentrated under reduced pressure to obtain the entitled compound (7.4 g, 100%) as a yellow oil.

後処理

  1. customThe reaction liquid
  2. extractionextracted twice with chloroform
  3. dry with materialThe organic layer was dried with magnesium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-80fa6b369adb4d00944c6bf0b36ca069
出典データセット
uspto-grants-2012_04
特許番号
US08163770B2

反応ノート

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