Triethylamine → Ethyl 7-azetidin-1-yl-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

HRID 1696936ノート

反応式

HRID 1696936 の反応式
Cl[C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:8][N:9]2[CH2:12][CH2:13][C:14]#[N:15])=[CH:4][CH:3]=1.Cl.[NH:23]1[CH2:26][CH2:25][CH2:24]1.C(N(CC)CC)C>C(#N)C.O>[N:23]1([C:2]2[N:11]=[C:10]3[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:8][N:9]3[CH2:12][CH2:13][C:14]#[N:15])=[CH:4][CH:3]=2)[CH2:26][CH2:25][CH2:24]1

参加物

6

反応物 3

HCID 8471Triethylamine2 回HCID 12308726Azetidine hydrochlorideHCID 87333475Ethyl 7-chloro-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

生成物 1

HCID 67275510Ethyl 7-azetidin-1-yl-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6342Acetonitrile溶媒

実験手順

A solution of EXAMPLE 81B (16 g), azetidine hydrochloride (12.2 g) and triethylamine (21.9 mL) in acetonitrile (500 mL) was stirred for 2 hours, treated with triethylamine (900 mg), stirred for one hour, diluted with water (1.5 L), stirred for 1 hour, and filtered.

後処理

  1. stirringstirred for 1 hour
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-7288e3162c064e249db908c8feb139b9
出典データセット
uspto-grants-2012_04
特許番号
US08163769B2

反応ノート

読み込み中…