Acetic Anhydride → 3-(6-Bromo-naphthalen-2-yl)-5-methyl-[1,2,4]oxadiazole
反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:19]([NH:21]O)=[NH:20])[CH:13]=[CH:12]2>CC1C=C(C)C=C(C)N=1>[Br:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:19]1[N:20]=[C:5]([CH3:6])[O:7][N:21]=1)[CH:13]=[CH:12]2参加物
4
実験手順
6.11 ml acetic anhydride are added to 4.40 g 6-bromo-N-hydroxy-naphthalene-2-carboxamidine in 30 ml 2,4,6-trimethylpyridine. The reaction mixture is stirred for one hour at ambient temperature and then heated to 130° C. for four hours. After the reaction has ended the mixture is evaporated down in vacuo and the flask residue is stirred with ethyl acetate and petroleum ether, suction filtered and dried.
後処理
- temperatureheated to 130° C. for four hours
- customis evaporated down in vacuo
- stirringthe flask residue is stirred with ethyl acetate and petroleum ether, suction
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-5ce417c6628c48d1804740330ea7b28a
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163911B2
反応ノート
読み込み中…