Triethylamine → HCID 178513225、化合物

HRID 1697268ノート

反応式

HRID 1697268 の反応式
Cl.[NH2:2][OH:3].C(N(CC)CC)C.[Br:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]#[N:23])[CH:16]=[CH:15]2>C(O)C>[Br:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]([NH:2][OH:3])=[NH:23])[CH:16]=[CH:15]2

参加物

5

反応物 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 146621156-Bromonaphthalene-2-carbonitrile

生成物 1

HCID 178513225HCID 178513225、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.48 g hydroxylamine-hydrochloride and 5.68 ml triethylamine are added to 4.10 g of 6-bromo-2-cyano-naphthalene in 100 ml of ethanol and the reaction mixture is refluxed for four hours. After cooling to ambient temperature the solvent is distilled off in vacuo using the rotary evaporator and the flask residue is divided between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate and evaporated down.

後処理

  1. temperaturethe reaction mixture is refluxed for four hours
  2. distillationis distilled off in vacuo
  3. customthe rotary evaporator
  4. extractionThe aqueous phase is extracted with ethyl acetate
  5. customthe combined organic phases are dried on magnesium sulphate
  6. customevaporated down

出典と根拠

ORDレコード
ord-de8976d12e9940d2bc603ab462d1e8e3
出典データセット
uspto-grants-2012_04
特許番号
US08163911B2

反応ノート

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