HCID 59534044、化合物 → {[(3,5-Dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonic acid

HRID 1697278ノート

反応式

HRID 1697278 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:23][P:24](=[O:41])([O:33]CC2C=CC=CC=2)[O:25]CC2C=CC=CC=2)[C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1>CO.[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:23][P:24](=[O:25])([OH:33])[OH:41])[C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1

参加物

4

反応物 1

HCID 59534044HCID 59534044、化合物

生成物 1

HCID 25190980{[(3,5-Dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

72 mg dibenzyl {[(3,5-dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonate in 6 ml of methanol are hydrogenated in the presence of 3 mg palladium on activated charcoal (10% Pd). The catalyst is filtered through kieselguhr and the filtrate is evaporated down in vacuo. The flask residue is stirred with diisopropylether, suction filtered and dried.

後処理

  1. filtrationThe catalyst is filtered through kieselguhr
  2. customthe filtrate is evaporated down in vacuo
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-e7f40591e54b4352a2d37238b414ed2a
出典データセット
uspto-grants-2012_04
特許番号
US08163911B2

反応ノート

読み込み中…