Lithium Hydroxide → 4-(2-Trifluoromethyl-benzenesulfonyl)-1-(3-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic Acid
反応式
C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])(=[O:13])=[O:12])[CH2:8][N:7]1[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=1)=[O:5])C.[OH-].[Li+]>>[F:22][C:20]([F:21])([F:23])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[S:11]([CH:9]1[CH2:8][N:7]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)[CH:6]([C:4]([OH:5])=[O:3])[CH2:10]1)(=[O:12])=[O:13]参加物
3
実験手順
In analogy to the procedure described in example 253e, 4-(2-trifluoromethyl-benzenesulfonyl)-1-(3-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as white solid which was used in the next step without further purification. MS (ESI): m/z=468.1 [M+H]+.
出典と根拠
- ORDレコード
- ord-0054edeb59e3472aae082676e9c7f067