Formaldehyde → 1-(3-Cyano-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester
反応式
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]#[N:14])[CH:8]=1)[CH3:2].[CH2:16]=O.[CH:18]([S:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:29]([F:32])([F:31])[F:30])(=[O:22])=[O:21])=[CH2:19]>>[CH2:1]([O:3][C:4]([CH:5]1[CH2:16][CH:18]([S:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]([F:30])([F:32])[F:31])(=[O:21])=[O:22])[CH2:19][N:6]1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]#[N:14])[CH:8]=1)=[O:15])[CH3:2]参加物
4
実験手順
In analogy to the procedure described in example 343d, (3-cyano-phenylamino)-acetic acid ethyl ester (CAS Reg. No. 92316-76-2) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound as brown oil. MS (ESI): m/z=453.1 [M+H]+.