Trifluoroacetic acid → (2S,4R)-4-Cyclopropylmethanesulfonyl-pyrrolidine-2-carboxylic Acid Methyl Ester Trifluoroacetate
反応式
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([CH2:13][CH:14]2[CH2:16][CH2:15]2)(=[O:12])=[O:11])[CH2:7][N:6]1C(OC(C)(C)C)=O)=[O:4].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([CH2:13][CH:14]2[CH2:16][CH2:15]2)(=[O:11])=[O:12])[CH2:7][NH:6]1)=[O:4]参加物
3
実験手順
In analogy to the procedure described in example 409f, (2S,4R)-4-cyclopropylmethanesulfonyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (example 423c) was reacted with trifluoroacetic acid to give the title compound as yellow liquid.
出典と根拠
- ORDレコード
- ord-c9bb8d285dad4af9b52adf5f4c5841a1
- 出典データセット
- uspto-grants-2012_04
- DOI