反応式
C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH:8]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([CH3:29])([CH3:28])[CH3:27])=[CH:22][CH:21]=2)[NH:7]1)=[O:5])C.[OH-].[Li+]>>[C:26]([C:23]1[CH:22]=[CH:21][C:20]([CH:8]2[NH:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:10][CH:9]2[S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:25][CH:24]=1)([CH3:29])([CH3:27])[CH3:28]参加物
3
実験手順
In analogy to the procedure described in example 253e, 5-(4-tert-butylphenyl)-4-(phenylsulfonyl)pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as colorless solid which was used in the next step without further purification. MS (ESI): m/z=388.2 [M+H]
出典と根拠
- ORDレコード
- ord-14433362cc5e446a88da13f7ddbbfb03
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163793B2
関連ノート
読み込み中…