Lithium Hydroxide → (2S,4R)-4-(2-Chlorophenylsulfonyl)-1-(3-methyl-1-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxylic Acid
反応式
C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH2:7][N:6]1[C:20]1[N:24]([CH:25]2[CH2:30][CH2:29][S:28][CH2:27][CH2:26]2)[N:23]=[C:22]([CH3:31])[CH:21]=1)=[O:4].[OH-].[Li+]>>[Cl:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[S:10]([C@H:8]1[CH2:7][N:6]([C:20]2[N:24]([CH:25]3[CH2:30][CH2:29][S:28][CH2:27][CH2:26]3)[N:23]=[C:22]([CH3:31])[CH:21]=2)[C@H:5]([C:3]([OH:4])=[O:2])[CH2:9]1)(=[O:11])=[O:12]参加物
3
反応物 2
生成物 1
実験手順
In analogy to the procedure described in example 253e, (2S,4R)-4-(2-chlorophenylsulfonyl)-1-(3-methyl-1-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as brown liquid which was used in the next step without further purification. MS (ESI): m/z=470.0 [M+H]+.