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Water → 4-[3-t-Butyl-5-(3-naphthalen-1-yl-ureido)-pyrazol-1-yl]-benzoic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | alpha-Naphthyl isocyanate | HCID 66589 | — |
| 反応物 | methyl 4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoate | HCID 2973426 | — |
| 生成物 | 4-[3-t-Butyl-5-(3-naphthalen-1-yl-ureido)-pyrazol-1-yl]-benzoic acid ethyl ester | HCID 58842890 | — |
反応手順
To a solution of Example X (2.9 g, 10 mmol) in THF (50 mL) was added a solution of 1-naphthyl isocyanate (1.7 g, 10 mmol) in THF (20 mL) at 0° C. The mixture was stirred at RT for 1 h and heated until all solids dissolved. The mixture was then stirred at RT for 3 h and poured into water (200 mL). The precipitate was filtered, washed with diluted HCl and H2O, dried under vacuum to give 4.3 g of 4-[3-t-butyl-5-(3-naphthalen-1-yl-ureido)-pyrazol-1-yl]-benzoic acid ethyl ester, which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737283B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-53edbb55c33848469d34fdbcb4972bf7 |
| 出典メモ | uspto-grants-2010_06 |