Morpholine → HCID 59239393、化合物

HRID 1697894ノート

反応式

HRID 1697894 の反応式
[CH2:1]([N:8]1[CH2:16][C:15]2[C:14](Cl)=[N:13][C:12]([Cl:18])=[N:11][C:10]=2[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)C(C)C)(C)C.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>C(O)(C)C>[CH2:1]([N:8]1[CH2:16][C:15]2[C:14]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[N:13][C:12]([Cl:18])=[N:11][C:10]=2[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 592394402,4-Dichloro-5,6-dihydro-6-(phenylmethyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one

生成物 1

HCID 59239393HCID 59239393、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

6-benzyl-2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (cw) (0.125 g, 0.000425 mol), isopropyl alcohol (2.90 mL), N,N-diisopropylethylamine (0.150 mL, 0.861 mmol) and morpholine (0.0556 mL, 0.638 mmol) were mixed and the mixture was stirred for 30 minutes. The reaction mixture was concentrated. The resulting residue was chromatographed through silica gel (40 g, 0-5% MeOH in dichloromethane) to give the compound cx (0.126 g, 86%).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customThe resulting residue was chromatographed through silica gel (40 g, 0-5% MeOH in dichloromethane)
  3. customto give the compound cx (0.126 g, 86%)

出典と根拠

ORDレコード
ord-43f09ab8aa2e4c33ba2a514d5fc1a268
出典データセット
uspto-grants-2012_04
特許番号
US08163763B2

反応ノート

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