Sodium Iodide → HCID 59239158、化合物
反応式
Cl.[CH2:2]([NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:15]=[C:16]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)[C:17]3[CH2:23][CH2:22][NH:21][CH:20]([CH3:24])[C:18]=3[N:19]=2)=[CH:10][CH:9]=1)=[O:6])[CH3:3].Br[CH2:32][CH:33]1[O:37][CH2:36][CH2:35][O:34]1.[I-].[Na+]>>[O:34]1[CH2:35][CH2:36][O:37][CH:33]1[CH2:32][N:21]1[CH2:22][CH2:23][C:17]2[C:16]([N:25]3[CH2:26][CH2:27][O:28][CH2:29][CH2:30]3)=[N:15][C:14]([C:11]3[CH:10]=[CH:9][C:8]([NH:7][C:5]([NH:4][CH2:2][CH3:3])=[O:6])=[CH:13][CH:12]=3)=[N:19][C:18]=2[CH:20]1[CH3:24]参加物
4
実験手順
The compound sj was prepared following the general procedure in Example 296, substituting 1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt for 1-ethyl-3-(4-(8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt and substituting 1-bromo-2-methoxyethane for 2-(bromomethyl)-1,3-dioxolane. For this reaction, a catalytic amount Sodium iodide was also added: LC-MS m/z=483 (M+H).
後処理
- customThe compound sj was prepared