phenylmethyl 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxylate → 1-(Morpholine-4-carboxamido)cyclohexanecarboxylic acid

HRID 1698425ノート

反応式

HRID 1698425 の反応式
[N:1]1([C:7]([NH:9][C:10]2([C:16]([O:18]CC3C=CC=CC=3)=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CO.[Pd]>[N:1]1([C:7]([NH:9][C:10]2([C:16]([OH:18])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 17851014phenylmethyl 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxylate

生成物 1

HCID 115071371-(Morpholine-4-carboxamido)cyclohexanecarboxylic acid収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

In methanol was suspended 151 g (452 mmol) of phenyl-methyl 1-[N-(morpholine-4-carbonyl)amino]cyclohexane-carboxylate, 15 g of 5% palladium-active carbon was added to the suspension and the mixture was stirred under hydrogen stream at room temperature overnight. After removing the catalyst by filtration, the catalyst was washed three times with a mixed solvent of chloroform-methanol, and the organic layers were combined and the solvent was distilled off under reduced pressure to obtain 112 g (Yield: 100%) of the title compound.

後処理

  1. additionwas added to the suspension
  2. customAfter removing the catalyst
  3. filtrationby filtration
  4. washthe catalyst was washed three times with a mixed solvent of chloroform-methanol
  5. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-4324349418f64462ae875e7860bbd20e
出典データセット
uspto-grants-2012_04
特許番号
US08163943B2

反応ノート

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