1,2-Dibromoethane → HCID 178477283、化合物

HRID 1698494ノート

反応式

HRID 1698494 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH3:10])=[CH:4][CH:3]=1.[Mg:11].[Br:12]CCBr>C1COCC1>[CH2:9]([S:8][C:5]1[CH:6]=[CH:7][C:2]([Mg:11][Br:12])=[CH:3][CH:4]=1)[CH3:10]

参加物

5

反応物 3

HCID 78391,2-DibromoethaneHCID 5462224MagnesiumHCID 70066501-Bromo-4-(ethylthio)benzene2 回

生成物 1

HCID 178477283HCID 178477283、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

反応条件

温度
50 °C

実験手順

1-Bromo-4-(ethylthio)benzene (0.5 g, 2.3 mmol) was added to a stirred mixture of magnesium turnings (1.96 g, 82 mmol) in THF (10 mL). 1,2-Dibromoethane (30 μL) was then added and the mixture was heated at reflux to initiate the reaction. A solution of 1-bromo-4-(ethylthio)benzene (18.2 g, 84 mmol) in THF (60 mL) was added at such a rate to maintain the reaction mixture at gentle reflux. The reaction mixture was then stirred at 50° C. for 90 min and cooled to ambient temp to give a 1.16M solution of 4-(ethylthio)phenylmagnesium bromide in THF which was used in the next reaction.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux
  3. customthe reaction
  4. temperatureto maintain the reaction mixture at gentle reflux
  5. temperaturecooled to ambient temp

出典と根拠

ORDレコード
ord-98cd55c83df54854bb20f0310eca59fd
出典データセット
uspto-grants-2012_04
特許番号
US08163956B2

反応ノート

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