Thionyl Chloride → 2-Methoxy-4-methyl-6-(trifluoromethyl)-3-pyridinecarbonyl chloride

反応式

S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[N:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([CH3:20])[C:8]=1[C:9](O)=[O:10]>>[CH3:5][O:6][C:7]1[N:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([CH3:20])[C:8]=1[C:9]([Cl:3])=[O:10]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 67275887HCID 67275887、化合物

生成物 1

HCID 579598942-Methoxy-4-methyl-6-(trifluoromethyl)-3-pyridinecarbonyl chloride

反応条件

温度: 60 °C

実験手順

Thionyl chloride (2 mL) was added to 2-methoxy-4-methyl-6-(trifluoromethyl)-nicotinic acid (68 mg, 0.29 mmol) and then the mixture was heated at 60° C. for 1 hour. The mixture was evaporated to dryness.

後処理

customThe mixture was evaporated to dryness

出典と根拠

ORDレコード: ord-bc67254b6ea3462db0f616ee2eba139d
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08163956B2

反応ノート

読み込み中…