Tetrahydrofuran → Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate

HRID 1698567ノート

反応式

HRID 1698567 の反応式
[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[O:13]1CCC[CH2:14]1>>[O:13]=[C:14]1[NH:12][C:11]2[CH:10]=[CH:9][CH:8]=[C:3]([C:4]([O:6][CH3:7])=[O:5])[C:2]=2[NH:1]1

参加物

3

反応物 2

HCID 8028TetrahydrofuranHCID 5718252,3-Diaminobenzoic acid methyl ester

生成物 1

HCID 22745204Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate収率 84%

実験手順

To a solution of methyl 2,3-diaminobenzoate (10.5 g, 63.2 mmol) in tetrahydrofuran (100 mL) was added N,N′carbonyldiimidazole (10.2 g, 63.2 mmol), and the mixture was stirred at room temperature for 60 hours. The resulting solid was collected by filtration and washed with ethyl acetate to give 10.2 g (53.1 mmol, 84.0%) of the title compound as a colorless crystal.

後処理

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-e92ab6b4652c4729b09be4ed701c4878
出典データセット
uspto-grants-2012_04
特許番号
US08163935B2

反応ノート

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