Hydrazine hydrate (1:1) → 3-Fluoro-2-hydrazinylpyridine

HRID 1698677ノート

反応式

HRID 1698677 の反応式
Cl[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>C(O)C>[F:8][C:7]1[C:2]([NH:10][NH2:11])=[N:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 27827912-Chloro-3-fluoropyridine

生成物 1

HCID 269852863-Fluoro-2-hydrazinylpyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

To a solution of 9.59 g of 2-chloro-3-fluoropyridine in 6 ml of ethanol there was added 6 ml of hydrazine monohydrate, and the mixture was stirred at 60° C. for 3 days. The solution was adsorbed onto 50 g of NH silica gel and purified by NH silica gel column chromatography (ethyl acetate-heptane) to give the title compound (403 mg) as a yellow solid.

後処理

  1. custompurified by NH silica gel column chromatography (ethyl acetate-heptane)

出典と根拠

ORDレコード
ord-b75bb6c2fbbf4bf9aa08745c4826350e
出典データセット
uspto-grants-2012_04
特許番号
US08163787B2

反応ノート

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