Trifluoroacetic acid → HCID 136173806、化合物
反応式
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[C:25](=[O:26])[NH:24][C:23]([CH:27]([C:41]2[CH:46]=[C:45]([CH2:47][CH3:48])[CH:44]=[C:43]([O:49][CH2:50][C:51](=[O:55])[N:52]([CH3:54])[CH3:53])[C:42]=2[F:56])[NH:28][C:29]2[CH:34]=[CH:33][C:32]([C:35]3[N:39]=[C:38]([CH3:40])[O:37][N:36]=3)=[CH:31][CH:30]=2)=[N:22]1)(C)(C)C>ClCCl>[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[C:25](=[O:26])[NH:24][C:23]([CH:27]([NH:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]3[N:39]=[C:38]([CH3:40])[O:37][N:36]=3)=[CH:33][CH:34]=2)[C:41]2[C:42]([F:56])=[C:43]([CH:44]=[C:45]([CH2:47][CH3:48])[CH:46]=2)[O:49][CH2:50][C:51]([N:52]([CH3:54])[CH3:53])=[O:55])=[N:22]1参加物
4
実験手順
After adding 2 ml of trifluoroacetic acid to a solution of 0.135 g of [2-(3-{(3-dimethylcarbamoylmethoxy-5-ethyl-2-fluorophenyl)-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino]methyl}-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl)phenyl]carbamic acid t-butyl ester in 10 ml of dichloromethane, the reaction mixture was stirred at room temperature for 4 hours, and the solvent was removed under reduced pressure. Next, 50 ml of ethyl acetate and 5 ml of 5% aqueous potassium carbonate were added to the residue, and the organic layer was washed with 20 ml of water and 20 ml of saturated aqueous sodium chloride in that order. The aqueous layer was extracted with 50 ml of ethyl acetate, and then the organic layers were combined and dried over anhydrous magnesium sulfate, the desiccating agent was filtered off and the filtrate was concentrated under reduced pressure. The title compound (0.100 g) was obtained as a white solid.