Sodium hydride → 2-(2-Phenylpropyl)-2-trifluoromethyl-oxiran

反応式

O[C:2]([C:24]([F:27])([F:26])[F:25])([CH2:15][CH:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:17])[CH2:3][O:4]S(C1C=CC(C)=CC=1)(=O)=O.[H-].[Na+]>CN(C)C=O.O>[C:18]1([CH:16]([CH3:17])[CH2:15][C:2]2([C:24]([F:27])([F:26])[F:25])[CH2:3][O:4]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

実験手順

400 mg of 4-toluenesulfonic acid-(2-hydroxy-4-phenyl-2-trifluoromethyl-pentyl)ester in 5 ml of dimethylformamide is mixed at 0° C. with 35 mg of sodium hydride (80% in mineral oil). After one hour at 0° C., it is diluted with water and extracted with dichloromethane. The dichloromethane phase is washed with water, dried (Na2SO4) and concentrated by evaporation. The residue is distilled. 200 mg of 2-(2-phenylpropyl)-2-trifluoromethyl-oxiran, boiling point 110° C./1 hPa, is obtained.