Dimethyl Sulfate → Methyl 5-t-butyl-1-methyl-3-nitropyrrole-2-carboxylate

HRID 1698919

反応式

HRID 1698919 の反応式
[C:1]([C:5]1[NH:9][C:8]([C:10]([O:12][CH3:13])=[O:11])=[C:7]([N+:14]([O-:16])=[O:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].S(OC)(O[CH3:21])(=O)=O.[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)C1C=CC=CC=1.C(Cl)Cl>[C:1]([C:5]1[N:9]([CH3:21])[C:8]([C:10]([O:12][CH3:13])=[O:11])=[C:7]([N+:14]([O-:16])=[O:15])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 18322358methyl 5-tert-butyl-3-nitro-1H-pyrrole-2-carboxylate

生成物 1

HCID 18322374Methyl 5-t-butyl-1-methyl-3-nitropyrrole-2-carboxylate

試薬・触媒・溶媒 2

HCID 2724282Benzenemethanaminium, N,N,N-tributyl-, bromide触媒HCID 6344Dichloromethane溶媒

実験手順

To a cold (0-10° C.) solution of methyl 5-tert-butyl-3-nitropyrrole-2-carboxylate (0.100 g, 0.44 mmol), benzyltributylammonium bromide (0.16 mg, 0.44 mmol, 1 equiv), and dimethyl sulfate (46 μL, 0.49 mmol, 1.1 equiv) in CH2Cl2 (1 mL) was added a 50% NaOH solution (0.21 g, 2.65 mmol, 6 equiv). After 5 min, the cooling bath was removed and the mixture was stirred at room temp. for 4 h. The reaction mixture was diluted with CH2Cl2, washed with water and a 10% NH4OAc solution (2x), dried (Na2SO4), and concentrated under reduced pressure to give a bright yellow oil. The oil was purified by flash chromatography (70% CH2Cl2/hexane) to give methyl 5-tert-butyl-1-methyl-3-nitropyrrole-2-carboxylate as a pale yellow oil which solidifies upon standing (0.061 g, 62%): 1H NMR (CDCl3) δ1.38 (s, 9H)., 3.80 (s, 3H), 3.92 (s, 3H), 6.47 (s, 1H).

後処理

  1. customthe cooling bath was removed
  2. additionThe reaction mixture was diluted with CH2Cl2
  3. washwashed with water
  4. dry with materiala 10% NH4OAc solution (2x), dried (Na2SO4)
  5. concentrationconcentrated under reduced pressure
  6. customto give a bright yellow oil
  7. customThe oil was purified by flash chromatography (70% CH2Cl2/hexane)

出典と根拠

ORDレコード
ord-b2d3ecb9c20f410bad57fd90f4b50329
出典データセット
uspto-grants-2002_02
特許番号
US06344476B1

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