Water → 4-[4-Sulfonylchromanoyloxy]-2-methoxybenzoic acid

HRID 1699

反応式

HRID 1699 の反応式
[S:1](=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[O:7][CH:6]([C:14]([O:16][C:17]2[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[C:19]([O:27][CH3:28])[CH:18]=2)=[O:15])[CH2:5]1)(=[O:3])=[O:2].O.O[Li].O>C1COCC1>[S:1](=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[O:7][CH:6]([C:14]([O:16][C:17]2[CH:26]=[CH:25][C:20]([C:21]([OH:23])=[O:22])=[C:19]([O:27][CH3:28])[CH:18]=2)=[O:15])[CH2:5]1)(=[O:2])=[O:3]

参加物

5

反応物 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 19691028Methyl 4-[4-sulfonylchromanoyloxy]-2-methoxybenzoate

生成物 1

HCID 196909464-[4-Sulfonylchromanoyloxy]-2-methoxybenzoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
45 °C

実験手順

To a stirred solution of methyl 4-[4-sulfonylchromanoyloxy]-2-methoxybenzoate (500 mg, 1.38 mmol) in THF:H2O (18 mL: 2 mL) was added LiOH.H2O (175 mg, 4.14 mmol). The reaction was heated to 45° C. over 12 h and then cooled to ambient temperature. The solvent was removed under reduced pressure. The crude solid was passed through a plug of silca gel packed in 50:50 MeOH:CH2Cl2 and eluted with same. The solvent was removed under reduced pressure to afford 4-[4-sulfonylchromanoyloxy]-2-methoxybenzoic acid as a white solid.

後処理

  1. temperaturecooled to ambient temperature
  2. customThe solvent was removed under reduced pressure
  3. washCH2Cl2 and eluted with same
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-46bdac7b5dca4dd2b9ea60dfb2c0fdfb
出典データセット
uspto-grants-1998_03
特許番号
US05726172

関連ノート

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