Hydrogen Bromide → 1-(Bromomethyl)-4-(2-methylpropyl)benzene

HRID 1699007ノート

反応式

HRID 1699007 の反応式
[BrH:1].[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12]O)=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]>CCOCC>[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][Br:1])=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 14620446[4-(2-Methylpropyl)phenyl]methanol

生成物 1

HCID 146204471-(Bromomethyl)-4-(2-methylpropyl)benzene

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

HBr gas was bubbled through a solution of (4-isobutyl-phenyl)-methanol (5 g, 28 mmol) in Et2O (50 mL) for 10-15 minutes. The reaction was stirred for 1 h and was poured onto ice (100 g). Et2O was added and the organic solution was washed with brine (2×). The organic solution was dried (MgSO4), filtered, and concentrated to provide the title compound (6 g). 1H NMR (400 MHz, CDCl3) δ7.28 (d, 2H), 7.10 (d, 2H), 4.49 (s, 2H), 2.45 (d, 2H), 1.84 (m, 1H), 0.89 (d, 6H).

後処理

  1. additionwas poured onto ice (100 g)
  2. washthe organic solution was washed with brine (2×)
  3. dry with materialThe organic solution was dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-64d1464bc70f4693a96514d804ef5629
出典データセット
uspto-grants-2002_02
特許番号
US06344485B1

反応ノート

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