Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine → Hexahydro-1-methyl-4-(4-piperidinyl)-1H-1 4-diazepine

HRID 1699262ノート

反応式

HRID 1699262 の反応式
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)[CH2:4][CH2:3]1>[OH-].[OH-].[Pd+2]>[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:4][CH2:3]1

参加物

3

反応物 1

HCID 18321160Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine

生成物 1

HCID 18321176Hexahydro-1-methyl-4-(4-piperidinyl)-1H-1 4-diazepine

試薬・触媒・溶媒 1

HCID 9942167Palladium hydroxide触媒

実験手順

Prepared analogously to Example A3f) from hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine by hydrogenolysis but using Pearlman's catalyst instead of palladium/charcoal, in a quantitative yield. Colourless viscous oil.

出典と根拠

ORDレコード
ord-76893da414004b26bf1c256909a01be2
出典データセット
uspto-grants-2002_02
特許番号
US06344449B1

反応ノート

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