Nitric Acid → HCID 18319578、化合物

HRID 1699399ノート

反応式

HRID 1699399 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C:6]=2[CH:16]=1.[N+:17]([O-])([OH:19])=[O:18]>O>[Cl:1][C:2]1[CH:3]=[C:4]([N+:17]([O-:19])=[O:18])[C:5]2[O:11][CH2:10][CH2:9][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C:6]=2[CH:16]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 18319616Methyl 2,3-dihydro-7-chloro-1-benzoxepin-4-carboxylate

生成物 1

HCID 18319578HCID 18319578、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Methyl 2,3-dihydro-7-chloro-1-benzoxepin-4-carboxylate (1.0 g) was added to nitric acid (4.5 ml, d=1.42) under ice-cooling and the mixture was stirred at ambient temperature for 2 hours. The mixture was poured into water and the isolated precipitate was collected by filtration to give methyl 2,3-dihydro-7-chloro-9-nitro-1-benzoxepin-4-carboxylate (1.04 g).

後処理

  1. temperaturecooling
  2. filtrationthe isolated precipitate was collected by filtration

出典と根拠

ORDレコード
ord-677bb8ffba894d519ccc92b793f0973c
出典データセット
uspto-grants-2002_02
特許番号
US06346527B1

反応ノート

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