Potassium Iodide → 4-(1-Piperazinyl)isoquinoline

HRID 1699446

反応式

HRID 1699446 の反応式
[CH2:1]1[C:10]2[C:5](=[C:6]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH:7]=C[CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C([N:19](CC)CC)C.[I-].[K+].ClCCCN1C(C)(C)C2C=CC=CC=2S1(=O)=O>CN(C=O)C>[N:11]1([C:6]2[C:5]3[C:10](=[CH:1][CH:2]=[CH:3][CH:4]=3)[CH:9]=[N:19][CH:7]=2)[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 8471TriethylamineHCID 986981-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazineHCID 701623242-(3-Chloroprop-1-yl)-3,3-dimethyl-2,3-dihydro-1,2-benzoisothia-zole 1,1-dioxide

生成物 1

HCID 117698304-(1-Piperazinyl)isoquinoline収率 43%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

1.1 g (5.2 mmol) of 1-(5-tetralinyl)piperazine, 1.5 ml of triethylamine and a trace of potassium iodide were added to a solution of 1.64 g (6.0 mmol) of 2-(3-chloroprop-1-yl)-3,3-dimethyl-2,3-dihydro-1,2-benzoisothiazole 1,1-dioxide in 40 ml of DMF. The reaction mixture was stirred at 100° C. for four hours and then poured in ice-water, and the resulting precipitate was filtered off with suction. Purification took place by recrystallization from isopropanol to result in 1 g (43%) of the product (melting point 140° C.).

後処理

  1. filtrationthe resulting precipitate was filtered off with suction
  2. customPurification
  3. customby recrystallization from isopropanol

出典と根拠

ORDレコード
ord-aee5bd8e029843db9cf1beeb61ee1bf1
出典データセット
uspto-grants-2002_02
特許番号
US06346622B1

関連ノート

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